Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

• Ketoconazole, itraconazole (used to manage fungal infection)
• Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
• Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
• Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
• Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

The top drugs-drug interactionsawi-may-be-drug-potential

Medication	Drug-Food Interactions
Nitrates (e.g., nitroglycerin)	Cialis (tadalafil)
Alpha-blockers (e.g.

Cialis medicine is manufactured by Lupin. Cialis is available in 10mg. Cialis medicine contains generic salt Content Tadalafil. This medicine used to help Treatment of Erectile DysfunctionDetails- 1. Brand name – Cialis 2. Generic – Tadalafil3. Dosage form – tablet4. Used – It is used to help Treatment of Erectile Dysfunction 5. Packaging – 4 tablets6. Strength – 10mg7. Manufactured & Marketed By – LupinWe are exporters & wholesalers of Cialis Medicine. Cialis medicine is available at discounted prices. We can provide the best price for Cialis. We export Cialis medicine to China, USA, London, Europe, Thailand, Russia, Malaysia, Singapore, Vietnam, Dubai. Warning: Cialis Medicine out of the reach and sight of children and away from pets, never share your medicines with others, and use this medication only for the indication prescribed. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. ATTENTION - Above mention price only for reference. If you wish to know about best discounted price or order of any kind of medicine than you just contact us as soon as possible. Please check our contact us page for complete details. Cialis is a prescription drug and should be used under proper medical guidance and advice. Do not share the medicine with others, since they may be suffering from a problem that is not effectively treated by this drug.• Keep all medicines out of the reach of children and away from pets, never share your medicines with others, and use this medication only for the indication prescribed.• The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Notice: The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you. Before eating/consuming any medicine kindly do consult with your doctor / Medical adviser / Nurse / Hospital /medicine Institution / Health advisor or pharmacist/ medicine healer. Do not indulge in self medication using internet information. Self medication can be dangerous.

Side Effects- Cialis can cause side effects, but only when taken properly. However, they are a relatively uncommon side effect. Some side effects can be more severe, while others not serious can be easily managed. Here are some common side effects of Cialis: Headache, Flushing, Dizziness, Sore throat, Stomach upset, Blurred vision, Dry mouth, Sensitivity to sunlight, Trouble sleeping, Insomnia, Drowsiness, Drowsiness, Nausea, Dry dizziness, Sweating, Increased sweating, Increased blood pressure. Important Disclaimer- These are not all possible side effects. If you notice any side effects not worth mentioning, mention them to your doctor / health advisor / chemist / health professional / nurse / pharmacist / medicine healer / hospital / health advisor or counselling / counsellor / homecer / counselling / home / Nurse / Hospital / health advisor / chemist / counselling / cancer / counselling / counsellor or seek medical advice right away, tell your doctor / nurse / hospital / health advisor / chemist / health professional / health advisor / therapist / counselling before taking Cialis. Self medication can also be dangerous.Package Size- 4 Packaging- 4 tablets per pack?- Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F).- Keep away from heat and moisture- Do not refrigerate- Shake the packaging after use. - Pack it with some water after use. - Store in the original package in order to protect from light. - Keep it out of the reach of children and away from pets, never share your medicines with others, and use this medication only for the indication prescribed. Warning- Do not use this medication if you are allergic to it or to any of its ingredients. - If you are taking nitrates (eg, isosorbide, nitroglycerin) or recreational drugs (eg, amyl nitrite, angiotensin type 2, angiotensin type 3, calcium containing drugs, such as aliskiren, rosiglitazone, tolterodifenacin, simethicone etc.), you should not use this medication. - If you have heart problems or stroke/heart failure, you should not use this medication. - If you have a liver problem, you should not use this medication.

As with any drug product, there may be side effects. Generally, patients who experience side effects usually get them within 12 to 24 hours after taking Tadalafil. Side effects usually resolve on their own within 48 hours. Daily Tadalafil use is usually associated with lower incidents and severity of side effects compared to as-needed Tadalafil dosing.

Most common Tadalafil side effects

• Headache
• Indigestion
• Back pain
• Muscle pain
• Flushing
• Stuffy nose

Some more serious side effects have been reported. While rare, it is important to stop taking Tadalafil and contact a doctor right away if any of the following occur:

• An erection will not go away (priapism). If you have an erection that lasts longer than 4 hours, get medical help right away. If not treated right away, priapism can permanently damage the penis.
• Sudden vision loss in one or both eyes. Sudden vision loss can be a sign of a serious eye problem called non-arteritic anterior ischemic optic neuropath (NAION).
• Sudden hearing decrease or hearing loss. Some may also have ringing in the ears (tinnitus) or dizziness.

For a complete list of possible side effects,.

Possible drug interactions

Some drugs/medications may interact with Tadalafil. You should not take Tadalafil if you are taking nitrates (such as nitroglycerin tablets or patches) because the combination of these with Tadalafil could significantly lower blood pressure and lead to fainting or even death. Additionally, do not take Tadalafil if you are taking Cisapride, other ED medications (e.g. Viagra), Adcirca, or Riociguat.

On your intake form, please be sure to provide AgelessRx with all medications, herbs, non-prescription drugs, or dietary supplements you use. Also be sure to report if you smoke, drink alcohol, or use illegal drugs, as some may interact with your medication.

For a complete list of possible drug interactions,.

Other important safety information

Patients who have a condition called “left ventricular outlet obstruction” from valvular problems or heart muscle enlargement may get side effects such as fainting or light-headedness. Because patients with recent heart attacks or stroke, heart pains (angina), heart failure, uncontrolled blood pressure or uncontrolled irregular heart beats, severe liver disease, and retinal eye problems have not been studied, Tadalafil (Cialis) is not recommended for these patients. There may be rare occurrences of priapism or painful, prolonged erections. This is a serious condition that requires immediate medical attention. Patients should seek prompt medical attention if their erection lasts longer than four hours.

After taking a single tablet, Tadalafil can remain in the body for up to two days. It can remain longer if patients have problems with their kidneys or liver, or they are taking certain other medications.

Note:All information included on this page is a summary. It may not cover all possible information. If you have questions about this medication, talk to a doctor, pharmacist, or healthcare provider.

​Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

• Patients with a history of stroke, heart attack, or high blood pressure should not take Tadalafil.
• Fainting or light-headedness may occur if Tadalafil is taken with caution in patients with fainting or light-headedness. This occurs most commonly during the first few days of taking Tadalafil and is more common with longer-term use.
• Retinal tears or other tear formation may occur, especially in patients who have been taking alpha-blocker medications for eye conditions like diabetes or hypertension.
• The drug can cause serious vision loss if taken with caution in patients with retinitis pigmentosa.
• Liver disease has occurred rarely with as-needed Tadalafil but is more likely to occur in patients who take daily doses of the drug.
• Patients with a history of heart conditions should talk with their doctor before taking this drug.

References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

Asst. Tadalafil. [Accessed on November 08th, 2023].2C, 5R, 6R, 8R, 9FSo.2R, 5R, 6R, 8R, 9FW. H. Sebald.B.okia. B. Richer.5R, 6R, 8R, 9FI. V. Sikker.6R, 9FJ. A. Recife.K. Gupta.8R, 10R, 12FM. P. G. Rodrigues. [Modified on December 08th, 2023].N. D.9FR.10R, 12FLima.11R, 13FCialis.12F, 15F, 16FPortman.17FT. Lee.18FS.18F, 17FC.19FY.20F

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